Letter by Brook regarding article, "Residential exposure to traffic is associated with coronary atherosclerosis".

Residential Exposure to Traffic Is Associated With Coronary Atherosclerosis

Background—Long-term exposure to fine-particulate-matter (PM2.5) air pollution may accelerate the development and progression of atherosclerosis. We investigated the associations of long-term residential exposure to traffic and fine particulate matter with the degree of coronary atherosclerosis. Methods and Results—We used baseline data on 4494 participants (age 45 to 74 years) from the German ...

A genome-wide trans-ethnic interaction study links the PIGR-FCAMR locus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic

Air pollution is a worldwide contributor to cardiovascular disease mortality and morbidity. Traffic-related air pollution is a widespread environmental exposure and is associated with multiple cardiovascular outcomes such as coronary atherosclerosis, peripheral arterial disease, and myocardial infarction. Despite the recognition of the importance of both genetic and environmental exposures to t...

Residential Proximity to Major Roads, Exposure to Fine Particulate Matter, and Coronary Artery Calcium: The Framingham Heart Study.

OBJECTIVE Long-term exposure to traffic and particulate matter air pollution is associated with a higher risk of cardiovascular disease, potentially via atherosclerosis promotion. Prior research on associations of traffic and particulate matter with coronary artery calcium Agatston score (CAC), an atherosclerosis correlate, has yielded inconsistent findings. Given this background, we assessed w...

Letter by Calvet et al regarding article, "Prevalence of coronary atherosclerosis in patients with cerebral infarction".

Chronic Residential Exposure to Particulate Matter Air Pollution and Systemic Inflammatory Markers

BACKGROUND Long-term exposure to urban air pollution may accelerate atherogenesis, but mechanisms are still unclear. The induction of a low-grade systemic inflammatory state is a plausible mechanistic pathway. OBJECTIVES We analyzed the association of residential long-term exposure to particulate matter (PM) and high traffic with systemic inflammatory markers. METHODS We used baseline data ...